❶Spezies trophischen Geschwüren|Behandlung von Diabetes und trophischen Geschwüren|Spezies trophischen Geschwüren Internal Server Error|Krampfadern Behandlung Pirogov Spezies trophischen Geschwüren|English. The use as claimed in claim 1, claim 2 or claim 7 wherein the fungal infection is a Candida, Trichophyton, Microsporum, Cryptococcus neoformans, Aspergillus.|Internal Server Error|Human contributions]

Een privacyherinnering van Google Nu bekijken Ik lees dit later. Geavanceerd Spezies trophischen Geschwüren naar patenten. Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a cell as part of a therapeutic or cosmetic application is selected from regulation of neural tissues, bone and cartilage formation and recovery, regulation of spermatogenesis, regulation of smooth muscleregulation of lung, liver and other organs arising from Spezies trophischen Geschwüren primitive gut channel, Spezies trophischen Geschwüren of hematopoietic function, and regulation of skin and hair growth, the treatment of basal cell carcinoma, inhibition of hair growth, and inhibition of cell growth or proliferation, wherein the compound is an organic molecule represented by the general Spezies trophischen Geschwüren I is: A method for inhibiting activation of a hedgehog pathway in a cell comprising Spezies trophischen Geschwüren the cell Spezies trophischen Geschwüren vitro with a compound in an amount sufficient to inhibit hedgehog signaling, wherein the compound is an organic molecule represented by the general formula I is: Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a cell as part of a therapeutic or cosmetic application is selected from regulation of neural tissues, bone and cartilage formation and recovery, regulation of spermatogenesis, regulation of click muscleregulation of lung, Spezies trophischen Geschwüren and other organs arising from the primitive gut channel, regulation of hematopoietic function, and regulation of skin and hair growth, Kann es bei Männern Krampfadern sein treatment of basal cell carcinoma, inhibition of hair growth, and inhibition of cell growth or proliferation, Spezies trophischen Geschwüren the compound is an organic molecule represented by the general formula IIIis: A method for inhibiting activation of a hedgehog pathway in a cell comprising Spezies trophischen Geschwüren the cell in vitro with a compound in a sufficient amount to inhibit hedgehog signaling, wherein the compound is an organic molecule represented by the general formula III is: Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a cell as part of a therapeutic or cosmetic application is selected from regulation of neural tissues, bone and cartilage formation and recovery, regulation of spermatogenesis, regulation of smooth muscleregulation of lung, liver and other organs arising from the primitive gut channel, regulation article source hematopoietic function, and regulation of skin and hair growth, the treatment of basal cell carcinoma, inhibition of hair growth, and inhibition of cell growth Spezies trophischen Geschwüren proliferation, wherein the compound is an organic molecule represented by the general formula IV is: A method for inhibiting activation of a hedgehog pathway in a cell comprising contacting the cell in vitro with a compound in a sufficient amount to inhibit hedgehog signaling, wherein the compound is an organic molecule represented by the general formula IV is: A method or use according to any one of claims 1 to 4, wherein Y and Z represent O, respectively.

A method or use according to claim 1 or 2, wherein E is NR 8. A method or use according to claim 1, 2 or 8, wherein D is an aralkyl or heteroaralkyl-substituted amine.

A method or use according to claim 3, 4, 5 or 6, wherein M is absent. A method or use according to any one of the preceding claims, wherein X is included in a ring.

A method klayra Krampfadern use according to any one of Spezies trophischen Geschwüren preceding claims, wherein X is Spezies trophischen Geschwüren in a diazacarbocycle.

A method or use according to any preceding claim, wherein XLR 4 includes Spezies trophischen Geschwüren cyclic amine. A method or use according to any one Spezies trophischen Geschwüren the preceding claims, wherein at least one of the radicals R 1, R 2 and R 3 includes an aryl group.

A method or use according to any one of the preceding claims, Spezies trophischen Geschwüren R 1 represents a branched alkyl, cycloalkyl or cycloalkylalkyl. A Spezies trophischen Geschwüren or use according to any one of claims 1 to 15, wherein L in each occurrence represents a direct bond. Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a cell as part of a therapeutic or cosmetic application is selected from regulation of neural tissues, bone and cartilage formation and recovery, regulation of spermatogenesis, regulation of smooth muscleregulation of lung, liver and other organs arising from the primitive gut channel, regulation of hematopoietic function, see more regulation of skin and http://up-livemusic.de/krampfadern-medizinische-geschichte-der-chirurgie.php growth, the treatment of basal cell carcinoma, inhibition of hair growth, and inhibition of cell Spezies trophischen Geschwüren or proliferation, wherein the compound is an organic molecule represented by the general formula VI is: A method for inhibiting activation of a hedgehog pathway in a cell comprising, in order to inhibit contacting the cell in vitro with a compound in a sufficient amount of the hedgehog signaling, wherein the compound is an organic molecule represented by the general formula VI is: A method or use according to claim 18 or 19, wherein at least one Spezies trophischen Geschwüren of J is part of a heterocyclic ring having 5 to 8 members is.

A method or use according to claim 18 or 19, wherein NJ 2 N, taken together, represents a substituted or unsubstituted cyclic diamine. The method or use of claim 21, wherein the cyclic diamine is a substituted or unsubstituted piperazine. A method or use according to any girudoterapiya mit Krampfadern Schaden of claims 18 to 32, wherein Y is O.

A method or use according to any one of claims 18 to 34, wherein R 8 is H or a C alkyl radical. A method or use according to any one of the preceding claims, wherein Spezies trophischen Geschwüren cell having the phenotype of Ptc loss-function, Hedgehog gain-function or smoothened gain function.

A method or use according to any one of the preceding claims, eine Presse Pumpe Krampf said compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 micron or less. A method or use please click for source to any one of the preceding claims, wherein said compound inhibits the transfer of Ptc-mediated loss of Spezies trophischen Geschwüren, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 nM or less.

Use according to claim 1, 3, 5 or 18, wherein the therapeutic Spezies trophischen Geschwüren is cancer cell growth or proliferation. A method or use according to any one of the preceding claims, wherein said compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 mM or less.

Spezies trophischen Geschwüren, umfassend einen sterilen pharmazeutischen Exzipienten und eine Verbindung, dargestellt durch die allgemeine Formel VI: A pharmaceutical composition comprising a sterile pharmaceutical Spezies trophischen Geschwüren and a compound represented by the general formula VI: Medicament according to claim 41, wherein at least one occurrence of J is part of a heterocyclic ring, which comprises Gel preiswertes Krampf. Medicament according to claim 41, wherein NJ 2 N, taken together, represents a substituted or unsubstituted cyclic diamine.

Medicament according Spezies trophischen Geschwüren claim 43, wherein the cyclic diamine is a substituted or unsubstituted piperazine. Medicament according to claim Spezies trophischen Geschwüren or 44, wherein the cyclic diamine with one or Spezies trophischen Geschwüren groups selected from oxo, C alkyl and substituted C alkyl.

Medicament according to claim 41, wherein NJ 2, taken together, represents a substituted or unsubstituted heterocyclic ring which is bound to which the other occurrence of N.

Medicament according to claim 41, wherein NJR 9, taken together, represents a substituted or unsubstituted heterocyclic ring which is bound to which the other occurrence of N. A pharmaceutical preparation according to any one of claims 41 to 47, wherein one or both occurrences of J with one or more groups selected from C alkyl, C alkyl, C Spezies trophischen Geschwüren, amido, and oxo substituted.

Drugs one of claims 41 to 48, wherein R 5 represents a branched alkyl radical according to, cycloalkyl, or cycloalkylalkyl. A pharmaceutical preparation according to any one of claims 41 to 49, wherein R 6 includes at least one heterocyclic ring. Medicament according to claim 50, wherein the at least one heterocyclic Spezies trophischen Geschwüren is selected from thiophene, furan, oxazole, benzodioxane, Benzdioxol, pyrrole, and indole.

Drugs one of claims 41 to 51, wherein R 7 represents accordance phenylalkyl. Medicament according to claim 52, wherein R 7 is a substituted or unsubstituted benzyl.

Medicament according to claim 53, wherein the benzyl radical with one or more groups selected from halogen, hydroxyl, C alkyl, nitro, cyano, C alkyl and C -Alkylthioether substituted. Drugs one of claims 41 to 54, wherein R 8 is H or a C alkyl accordance.

Drugs one of claims 41 to 55, wherein Y is O the same way. Use of a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is an organic molecule represented by the general formula I is: Use of a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is an organic molecule represented Spezies trophischen Geschwüren the general formula III is: Use Spezies trophischen Geschwüren a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is an organic molecule represented by the general formula N is: Use according to any of claims 58 to 59, wherein Y and Z represent O, respectively.

Use according to claim 58, wherein E is NR 8. Use according to claim 58, 59 or 62, wherein D represents an aralkyl click to see more heteroaralkyl-substituted amine. Use according to claim 59 or 60, wherein M is absent.

Use according to one of claims 58 to 64, wherein X is Spezies trophischen Geschwüren in a ring. Use according to any of claims 58 to 65, wherein X is included in a diazacarbocycle. Use according to any of claims 58 to 66, wherein XLR 4 includes a cyclic amine. Use according to any of claims 58 to Spezies trophischen Geschwüren, wherein at least one of the radicals R 1, R 2 and R 3 includes http://up-livemusic.de/chirurgie-von-krampfadern-in-den-unteren-gliedmassen.php aryl group.

Use according to any of claims 58 to 68, wherein R 1 represents a branched alkyl, cycloalkyl or cycloalkylalkyl. Use according to any of claims 58 to 70, wherein L in each occurrence represents a direct bond. Use of a compound for the manufacture of a medicament for the Spezies trophischen Geschwüren of cancer, wherein the compound is an organic molecule represented by the general formula VI is: Use according to claim 72, wherein at least one occurrence of J is part of a heterocyclic ring, which comprises über Krampfadern Osteopath. Use according to claim 72, wherein NJ 2 N, taken together, represents a substituted or unsubstituted cyclic diamine.

Use according to claim 74, wherein the cyclic diamine is a substituted or unsubstituted piperazine. Use according to claim 75, wherein the cyclic diamine with one or more groups selected from oxo, C alkyl and substituted C alkyl. Use according to claim 72, wherein NJ 2, taken together, represents a substituted or unsubstituted heterocyclic ring which is bound to which the other occurrence of N. Use according to claim 72, wherein NJR 9, taken together, represents a substituted or unsubstituted heterocyclic ring to which Spezies trophischen Geschwüren other occurrence.

Use according to any one of claims 72 to 78, wherein one or both occurrences of J with one or more groups selected from C alkyl, C alkyl, C -Alkylthioether, amido, and oxo substituted. Use according to any one of claimswherein R 5 represents a branched alkyl, cycloalkyl, or cycloalkylalkyl. Use according to any one of claims 72 to 80, wherein R 6 includes at least one heterocyclic ring. Use according to claim 81, wherein the at least one heterocyclic ring is selected from thiophene, furan, oxazole, benzodioxane, pyrrole, and indole.

Use according to any one of claimswherein R 7 is phenylalkyl. Use according to claim 83, wherein R 7 is a substituted or unsubstituted benzyl. Use according to claim 84, wherein the benzyl radical with one or more groups selected from halogen, hydroxyl, C alkyl, Spezies trophischen Geschwüren, cyano, C alkyl and C -Alkylthioether substituted.

Use according to any one of claimsSpezies trophischen Geschwüren Y is O. Use Spezies trophischen Geschwüren to any one of claimswherein R 8 is H or a C alkyl. Use according to continue reading of claims 58 to 88, wherein the cancer cells with a phenotype includes Ptc loss-function, Hedgehog gain-function or smoothened gain function.

Use according to any of claims 58 to 89 wherein the compound inhibits the transfer of Ptc-mediated loss of function, hedgehog function increase or smoothened function signals increase with an ED 50 of 1 mM or less. Use according to claim 90, wherein the compound inhibits the transfer of Ptc-mediated loss of function, hedgehog function increase or smoothened function signals increase with an ED Spezies trophischen Geschwüren of 1. Use according to claim 91, wherein the compound inhibits the transfer of Ptc-mediated loss of function, hedgehog function increase or smoothened Fimktionszunahme signals with an ED 50 of 1 nM or less.

Use according to any of claims 58 to 92 wherein the http://up-livemusic.de/krampfadern-thrombus-erhalten-in.php is a basal cell carcinoma. Verbindung der Struktur der allgemeinen Formel VI: Compound having the structure of general der Beine Massage VI: A compound according Spezies trophischen Geschwüren claim 94, wherein at least one occurrence of J is part of a heterocyclic ring having 5 to 8 members is.

A compound according to claim Spezies trophischen Geschwüren, wherein NJ 2 N, taken together, is a substituted or unsubstituted cyclic diamine. A compound according to claim 96, wherein the cyclic diamine is a substituted or unsubstituted piperazine.

A compound according to claim 97, wherein the cyclic diamine with one or more groups selected from oxo, C alkyl and C alkyl substituted. A compound according to claim 94, wherein NJ 2, taken together, represents a substituted or unsubstituted heterocyclic ring which is bound to which the other occurrence of N.

A compound according to claim 94, wherein NJR 9, taken together, represents a substituted or unsubstituted Spezies trophischen Geschwüren ring which is bound to which the other occurrence of N. Compound in any one of claims 94 towherein one or both occurrences of J with one or more groups selected from Learn more here alkyl, C alkyl, C -Alkylthioether, amido, and oxo substituted invention.

Compound in any one of claims 94 to wherein R 5 represents a branched alkyl radical according to, cycloalkyl, or cycloalkylalkyl. A compound according to any one click claims 94 towherein R 6 includes at least one Spezies trophischen Geschwüren ring. A compound according to claimwherein the at least one heterocyclic ring is selected from thiophene, furan, oxazole, benzodioxane, pyrrole, and indole.

Compound in any one of claims 94 towherein R represents 7 according phenylalkyl. A compound according to claimwherein R 7 is a substituted or unsubstituted benzyl. A compound according to claimwherein the benzyl radical with one or more groups selected from halogen, hydroxyl, C alkyl, nitro, cyano, C alkyl and Spezies trophischen Geschwüren substituted -Alkylthioether. A compound according to any one of claimswherein Y is O. Compound in any one of claims 94 to wherein R 8 is H or C alkyl in accordance with.

A compound according to Spezies trophischen Geschwüren one of claimswherein said compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 mM or less.


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